The Wiley Protocol® is a trademarked, patent pending hormone replacement therapy (HRT) delivery system.  It consists of biomimetic estradiol and progesterone in a topical cream preparation -- dosed to mimic the natural hormones produced by your body when you were 20 years-old.

The creams and their amounts are designed to vary throughout the 28 day cycle because your youthful hormone levels naturally fluctuate. The Wiley Protocol targets age 20 as a baseline because heart disease and stroke, Type II diabetes, cancer and Alzheimer’s disease are not usual concerns for a healthy young individual. Approximately 80% of women with a uterus who have used the WP have had perfectly normal regular menstrual periods every 28 days. It is recommended that women without a uterus use the Wiley Protocol Lunar Calendar™* (See Calendar Definition section.)