The Wiley Protocol® is a trademarked, patent pending delivery system consisting of biomimetic estradiol and progesterone in a topical cream preparation dosed to mimic the natural hormones produced by your body when you were 20 years-old. The creams and their amounts vary throughout the 28 day cycle to mimic the hormone levels of youth when heart disease and stroke, Type II diabetes, cancer and Alzheimer’s disease weren’t immediate concerns. Approximately 80% of women with a uterus will have perfectly normal regular menstrual periods every 28 days. Women without a uterus use the Wiley Protocol® Lunar Calendar™.