The estrogen and progesterone hormones creams should be applied on separate limbs and into your fat base. Apply the estrogen to one limb (your arm or inner thigh) and the progesterone to separate limb. Do not mix the creams. Use separate hands for each cream. You also want to put some cream into thin skin, especially while you are building up a deposit in your fat base. Avoid sun damaged areas or abdominal skin.  Note that the Registered Pharmacies provide patient instruction sheets with drawings.