Natural Hormones Sanctioned by the Government

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Bio-identical HRT (BHRT) involves treatment with hormones synthesized in a lab to have the exact molecular structure as those made by your body. This is what makes them eligible for the term “natural”, and also what allows them to produce the same physiologic response when dosed correctly (as all of these are not) as those that are naturally produced by your body.

Compounded HRT from compounding pharmacies is made with the same variation of raw materials derived from plants as the products listed below termed “bio-identical” are. The difference is that in “compounded” BHRT, only the raw materials have been FDA approved. On the list below the bio-identical products are FDA approved as products. All of them provide very little in a dose and the doses are static and chronic without a rhythm that’s anything like the one you had when you were young. Cycling alone is not mulit-phasic rhythmic dosing. The one that says “pulsed” means like birth control pills.

When it says they are bio-identical, but lists them as “synthetic”, it simply means they are not plant-derived or half-botanical. Instead, they are completely made out substances (chemically derived) in the lab, but they are made to be identical to the molecules produced in the human body.

The Synthetics of the Standard of Care like Premarin, Provera and PremPro are not just patented drugs, they are patented molecules. The molecules of Synthetics of SOC must be architected to be unique in the world in order to be patented, because as the law stands now, it is impossible to patent a natural substance for which a molecular construct already exists in nature – like water, or human hormones.


Brand Name	Type/Generic Name	Route of Administration	Strength (mg)	Source of Active Ingredients	Dosing	Bioidentical
Premarin	Conjugated estrogens	Oral Vaginal cream	0.3 0.625 0.9 1.25 2.5 0.625	Pregnant mares' urine	Continuous	NO
Cenestin	Conjugated estrogens	Oral	0.625 0.9 1.25	Synthesized from soy and yams	Continuous	NO
EstraTab	Esterified estrogens (estrone, equilin)	Oral	0.625	Both estrone and equilin are synthesized from soy and yams	Continous	NO
Menest	Esterified estrogens (estrone, equilin)	Oral	0.3 0.625 1.25 2.5	Both estrone and equilin are synthesized from soy and yams	Continuous	NO
Estrace	Micronized estradiol	Oral Vaginal cream	0.5 1 2 0.01%	Synthesized from soy and yams	Continuous	YES
Ogen	Estropipate	Oral Vaginal cream	0.625 1.25 2.5 1.5	Synthesized from Mexican yams	Continuous	NO
Ortho-Est	Estropipate	Oral	0.625 1.25 2.5	Synthesized from yams	Continuous	NO
Estinyl	Ethinyl estradiol	Oral	0.625 1.25 2.5	Synthesized from Mexican yams	Continuous	NO
Alora	Estradiol	Transdermal Patch	0.05 0.075 0.1	Synthetic	Continuous	YES
Climara	Estradiol	Transdermal Patch	0.05	Synthesized from soybeans	Continuous	YES
Estraderm	Estradiol	Transdermal Patch	0.05 0.1	Synthesized from Mexican yams	Continuous	YES
FemPatch	Estradiol	Transdermal Patch	0.25	Synthetic	Continuous	YES
Vivelle/Vivelle-Dot	Estradiol	Transdermal Patch	0.0375 0.05 0.075 0.1	Synthesized from Mexican yams	Continuous	YES
Activella	Estradiol/Norethindrone acetate	Oral	1 0.5	Synthetic Synthetic	Continuous	NO
Estring	Estradiol	Vaginal ring	2	Synthesized from Mexican yams	Continuous	YES
Depo-Estradiol	Estradiol cypionate	Intramuscular	5	Synthetic	Monthly
Delestrogen	Estradiol valerate	Intramuscular	10 20 40	Synthetic	Monthly	NO
PremPro	Conjugated estrogens / Medroxyprogesterone acetate	Oral (One pack has two tablets w/ different strengths)	0.625 (Strength 1) 0.625 (Strength 2) 5 (Strength 1) 2.5 (Strength 2)	Pregnant mares' urine Synthetic	Continuous	NO
Premphase	Conjugated estrogens / Medroxyprogesterone acetate	Oral (One pack has two tablets w/ different strengths)	0.625 (Tablet 1) 0.625 (Tablet 2) 0 (Tablet 1) 5 (Tablet 2)	Pregnant mares' urine Synthetic	Cyclic	NO
EstraTest HS	Esterified estrogens / Methyltestosterone acetate	Oral	0.625 1.25	Synthesized from soy and yams Synthetic	Continuous	NO
EstraTest	Esterified estrogens / Methyltestosterone acetate	Oral	1.25 2.5	Synthesized from soy and yams Synthetic	Continuous	NO
Femhrt	Ethinyl estradiol/Norethindrone acetate	Oral	0.005 1	Synthesized from soy	Continuous	NO
OrthoPrefest	Estradiol / Norgestimate	Oral (One pack has two tablets w/ different strengths)	1 (Tablet 1) 1 (Tablet 2) 0 (Tablet 1) 0.09 (Tablet 2)	Synthesized from soy Synthetic	Pulsed	NO
Combipatch	Estradiol / Norethindrone acetate	Transdermal Patch	0.05 (Strength 1) 0.05 (Strength 2) 0.14 (Strength 1) 0.25 (Strength 2)	Synthesized from soy Synthesized from yams	Continuous	NO
Prometrium	Micronized progesterone	Oral	100 200	Synthesized from Mexican yams	Cyclic Continuous	YES
Crinone	Micronized progesterone	Vaginal Gel	4% 8%	Synthesized from Mexican yams	Cyclic Continuous	YES
Provera	Medroxyprogesterone acetate	Oral	2.5 5 10	Synthetic	Cyclic Continuous	NO
Cycrin	Medroxyprogesterone acetate	Oral	2.5 5 10	Synthetic	Cyclic Continuous	NO
Amen	Medroxyprogesterone acetate	Oral	2.5 5 10	Synthetic	Cyclic Continuous	NO
Aygestin	Norethindrone acetate	Oral	5	Synthetic	Cyclic	NO
Testoderm	Testosterone	Transdermal Patch	4 5 6	Synthetic	Continuous	YES
Androderm	Testosterone	Transdermal Patch	2.5 5	Synthesized from soy	Continuous	YES
Androgel	Testosterone	Transdermal Gel	2.5 50	Synthesized from yams or soy	Continuous	YES
Testim	Testosterone	Transdermal Gel	50	Synthesized from soy	Continuous	YES
Striant	Testosterone	Oral Gel	30	Synthesized from soy	Continuous	YES
Depo-testosterone	Testosterone cypionate	Intramuscular	100 mg/mL 200 mg/mL	Synthetic	Monthly or Twice/month	NO
Delatestryl	Testosterone enanthate	Intramuscular	100 mg/mL 200 mg/mL	Synthetic	Monthly or Twice/month	NO
Compound Pharmacy	Estrone / Estradiol / Estriol (Triple estrogen)	Oral / Transdermal / Sublingual / Vaginal	Customized	Synthesized from soy	Continuous	YES
Compound Pharmacy	Estradiol / Estriol (Bi-estrogen)	Oral / Transdermal / Sublingual / Vaginal	Customized	Synthesized from soy	Continuous	YES
Compound Pharmacy	Estriol	Oral / Transdermal / Sublingual / Vaginal	Customized	Synthesized from soy	Continuous	YES
Compound Pharmacy	Progesterone	Oral / Transdermal / Sublingual / Vaginal	Customized	Synthesized from yams or soy	Cyclic Continuous	YES
Compound Pharmacy	Testosterone	Oral / Transdermal / Sublingual / Vaginal	Customized	Synthesized from soy	Continuous	YES
Compound Pharmacy	Testosterone propionate	Intramuscular	Customized	Synthetic	Monthly or Twice/month	NO

Adapted from D Reed-Kane: International Journal of Pharmaceutical Compounding. Vol. 5 No. 5 September/October 2001

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