In 1993, approximately fifty years later, Animal People Magazine published an extensive article on the PMU farm abuses, also noting the suspected health risks to women taking PMU based medication. HRT drugs can now be 100% synthesized or organically compounded PMU free. In 1982, the U.S. Food and Drug Administration approved the use of insulin derived from recombinant-DNA techniques (using bacteria cultures) for diabetic patients who, heretofore, relied solely on insulin derived from the pancreases of pigs to control their disease.

The continued production of Premarin based medications produces revenues of 1.2 billion dollars annually for Wyeth-Ayerst Laboratories, the only pharmaceutical company which manufactures this product, of Wyeth Inc.'s 2002 net sales of 12 billion dollars world-wide, sales of Wyeth's Premarin branded drugs accounted for 13.35%.

Premarin, once the most prescribed drug in America (1975 to 1999), is now (2002) the fourth most prescribed drug in both the U.S. and Canada, holds 75% of the estrogen supplement market worldwide, and is Canada's most lucrative pharmaceutical export to date. Premarin,  a typical regimen, usually costs more than $800 per year to maintain, including insurance-deferred physicians fees. It ranks at number ten in Medicaid subsidized prescription drugs (subsidized by U.S. taxpayer dollars).

Sales of Premarin have already plummeted 30% (2003) from their high in 1999 and will continue to do so as more and more studies link the drug to life threatening ailments and women are made more aware of these studies.

Wyeth is already downplaying the use (as well as the length of use) of its Premarin family of drugs, a complete turn-around to the stance they followed for many years.

In July of 2003, federal regulators approved a lower-dose version of Premarin based HRT, and it is this lower dose that Wyeth is now recommending (specifically Prempro 0.45 mg/1.5 mg doses). Prempro 0.45 mg/1.5 mg contains 28% less estrogen and 40% less progestin than the current standard dose (Prempro 0.625 mg/2.5 mg).

Since the lower doses of Premarin based medications that Wyeth is now recommending are too new to have a research history, it is not possible to know if they will significantly lower the associated health risks in taking the medications. Wyeth is counting on that lie.

Wyeth will ask for approval of even lower doses in the future, until only traces of Premarin are present in the marketed drug. At which point, Premarin based HRT medications will be nothing more than an expensive placebo.